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Prof Leigh Ackland

STAFF PROFILE

Position

Personal Chair and Alfred Deakin Professor

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, University of Melbourne, 1993
Master of Science, University of Melbourne, 1976
Bachelor of Science, University of Melbourne, 1973

Contact

leigh.ackland@deakin.edu.au
+61 3 925 17036

Biography

After completing postgraduate studies at the Murdoch Childrens’ Research Institute (University of Melbourne), I commenced employment at Deakin University at the Rusden Campus in 1994. At that time at the Melbourne campuses there were no facilities for research in laboratory-based biology. I established the first biology research laboratory and initiated laboratory-based research at Rusden. In 2000, the Rusden laboratory was transformed into the Centre for Cellular and Molecular Biology (CCMB) at the Burwood campus. At its inception, the CCMB was focussed on metal biology in relation to humans. Since leading research in this facility from 2013, I have broadened its focus on metals to include research on plants, fungi, algae and bacteria, and introduced other aspects of human-based molecular biology including cancer and diabetes. This has been achieved by strategic appointments of new staff with a range of skills and experience. As deputy director of the Molecular and Medical Strategic Research Centre I have played a key role in building collaborations within and outside the university in the human bioscience discipline. My supervision of PhD students has been a major factor in facilitating the building of research projects and teams.

Read more on Leigh's profile

Career highlights

My most outstanding career highlight was to be conferred an Alfred Deakin Professor in 2018, for outstanding and sustained contribution to furthering Deakin's research and teaching, and the highest honour the University can bestow on a member of the academic staff.

In 2014 I was one of 26 international leading scientists invited to participate in the Ernst Strungman forum in Frankfurt, Germany to address key gaps in knowledge in global issues relating to Heavy Metals and Infectious Diseases,  and in 2007 the Australian Governmen nominated me as one of 10 scientists  to participate in the Indo-Australia Bioremediation Conference in Delhi, India.

Contribution to inquiry into Biofuels in the State Parliament of Victoria, 2007.

Over the last ten years I have played key roles in establishing international programs between Deakin University and universites in China and India, including the Chinese-Australian Joint Research Centre for Environmental Remediation and Health with the Chinese Academy of Science), and Deakin-TERI nanotechology programme in India.

In the last three years I have been successful in attracting major NHMRC and philanthropic funding for research into neuroendocrine tumors.

Invited Reviews

Ackland ML, Michalczyk AA. Invited Review. Zinc and infant nutrition. Arch Biochem Biophys. 2016 Jun 15. pii: S0003-9861(16)30197-7.

Hugo H, Ackland ML, Lawrence M, Clements J, Williams JD, Thompson EW. 2007. Epithelial - Mesenchymal and Mesenchymal - Epithelial Transitions in Solid Carcinoma Progression. J Cell Physiol 75th Aniversary Issue Invited Review 213 (2):374-83.

Ackland M L and Michalczyk A. Zinc deficiency and its inherited disorders – A review. 2006 Genes and Nutrition 1:41-50.

Research interests

Identifcation of novel markers to assist in improved detection and treatment of gastrointestinal neuroendocrine carcinomas and investigtion of drug resistance.

Multifunctional and environmentally friendly corrosion inhibitor systems.

Epigenetic factors that underlie the pathology of type 2 diabetes during pregnancy.

Molecular biology of zinc and copper in human diseases to understand zinc and copper fluxes in cells and elucidation of  inherited disorders in humans that result in the production of trace element-deficient milk during lactation.

Mechanisms underlying the spread of breast and neuroendocrine cancers termed “epithelial to mesenchymal transition” to understand why cancer cells metastasise

How nanoliposome can be used to deliver omega-3 fatty acids to brain cells.

Development of remediation strategies for heavy metal-contaminated soils and water.

Molecular basis of heavy metal tolerance in bacteria, fungi and plants.

Teaching interests

Introducing an understanding of the experimental basis of science and how research has shaped our understanding of biology

Knowledge areas

Cell and molecular biology and epigenetic processes in human disorders including cancers and type 2 diabetes, the biology of trace elements and heavy metals in bacteria, fungi, plants and animals

Expertise

Epithelial to mesenchymal transition in cancer progression. Biology of metals and metal transporters in prokaryote and eukaryote cells. Epigenetic basis of disease

Projects

Currently funded projects

Molecular proflling of of Gastrointestinal Neuroendocrine Carcinomas”. NHMRC Project APP1102018, $1,393,082.86 in 2016 and Bourne Foundation funding $000,000 in 2019.

Multifunctional and environmentally friendly corrosion inhibitor systems. ARC-DP180101465. $392,952 in 2018

Epigenetic factors in Diabetes. Greater Green Triangle, University of Melbourne  $45,000 in 2016.With a team of clinicians, we are investigating changers in histone methylation that occur in diabetes during pregnancy.

Past projects

Molecular biology of zinc and copper in human diseases to understand zinc and copper fluxes in cells and elucidation of  inherited disorders in humans that result in the production of trace element-deficient milk during lactation.

Mechanisms underlying the spread of breast cancer cells
Using a novel human breast cancer line we study the mechanisms of breast cancer metastasis termed “epithelial to mesenchymal transition”.

Nanoliposomal delivery of DHA to human neuronal cells. ARC Discovery Project- DP120101309.  2012-2014.  $280,000.

Development of remediation strategies for heavy metal-contaminated soils and water.

Molecular basis of heavy metal tolerance in plants where field trials of selected plants were used to remediate cadmium-contaminated soils and to establish the cellular mechanisms that enable plants to accumulate or resist heavy metals.

Publications

Filter by

2020

Chromium tolerance and accumulation in Aspergillus flavus isolated from tannery effluent

Shilpi Vajpai, Philip Taylor, Alok Adholeya, M Ackland

(2020), Vol. 60, pp. 58-71, Journal of basic microbiology, London, Eng., C1

journal article
2018

Critical effects of polar fluorescent probes on the interaction of DHA with POPC supported lipid bilayers

Kiera Flynn, Alessandra Sutti, Lisandra Martin, M Leigh Ackland, Angel Torriero

(2018), Vol. 1860, pp. 1135-1142, Biochimica et biophysica acta (BBA) - biomembranes, Amsterdam, The Netherlands, C1

journal article

Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes

A Michalczyk, E Janus, A Judge, P Ebeling, J Best, M Ackland, D Asproloupos, J Dunbar, M Ackland

(2018), Vol. 10, pp. 419-431, Epigenomics, London, Eng., C1

journal article
2017

Mechanism of docosahexaenoic acid in the enhancement of neuronal signalling

Bari, Gaburro, Michalczyk, Ackland, Catherine Williams, A Bhatti

(2017), pp. 99-117, Emerging trends in neuro engineering and neural computation, Singapore, B1

book chapter

Selective metal ion homeostasis in cyanobacteria

L Hudek, M Ackland

(2017), pp. 219-232, Prospects and challenges in algal biotechnology, Singapore, Singapore, B1

book chapter

Peroxide reduction by a metal-dependent catalase in Nostoc punctiforme (cyanobacteria)

L Hudek, A Torriero, A Michalczyk, B Neilan, M Ackland, L Bru

(2017), Vol. 101, pp. 3781-3800, Applied microbiology and biotechnology, Berlin, Germany, C1

journal article

Identifying epithelial endocytotic mechanisms of the peanut allergens Ara h 1 and Ara h 2

D Price, M Ackland, C Suphioglu

(2017), Vol. 172, pp. 106-115, International archives of allergy and immunology, Basel, Switzerland, C1

journal article
2016

Identification and topographical characterisation of microbial nanowires in Nostoc punctiforme

S Sure, A Torriero, A Gaur, L Li, Y Chen, C Tripathi, A Adholeya, M Ackland, M Kochar

(2016), Vol. 109, pp. 475-480, Antonie Van Leeuwenhoek, Cham, Switzerland, C1

journal article

Epigenetic markers to predict conversion from gestational diabetes to type 2 diabetes

A Michalczyk, J Dunbar, E Janus, J Best, P Ebeling, M Ackland, D Asproloupos, L Ackland

(2016), Vol. 101, pp. 2396-92404, Journal of clinical endocrinology and metabolism, Washington D.C., United States, C1

journal article

Zinc and infant nutrition

M Ackland, A Michalczyk

(2016), Vol. 611, pp. 51-57, Archives of biochemistry and biophysics, Amsterdam, The Netherlands, C1

journal article

Ceruloplasmin is regulated by copper and lactational hormones in PMC42-LA mammary epithelial cell culture models

D Freestone, D Denoyer, M Jakab, M Ackland, M Cater, A Michalczyk

(2016), Vol. 8, pp. 941-950, Metallomics, Cambridge, Eng., C1

journal article

Probing synechocystis-arsenic interactions through extracellular nanowires.

S Sure, M Ackland, A Gaur, P Gupta, A Adholeya, M Kochar

(2016), Vol. 7, pp. 1-12, Frontiers in microbiology, Lausanne, Switzerland, C1

journal article

Real-time quartz crystal microbalance monitoring of free docosahexaenoic acid interactions with supported lipid bilayers.

K Flynn, L Martin, M Ackland, A Torriero

(2016), Vol. 32, pp. 11717-11727, Langmuir: the ACS journal of surfaces and colloids, United States, C1

journal article

Microbial nanowires : an electrifying tale

S Sure, M Ackland, A Torriero, A Adholeya, M Kochar

(2016), Vol. 162, pp. 2017-2028, Microbiology, London, Eng., C1

journal article

Inhibition of the p53 Y220C mutant by 1-Hydroxy-2- Methylanthraquinone derivatives: a novel strategy for cancer therapy

V Ahire, D Das, K Mishra, G Kulkami, M Ackland

(2016), Vol. 35, pp. 355-364, Journal of Environmental Pathology, Toxicology and Oncology, Danbury, CT, C1

journal article
2015

Metals in the Environment as Risk Factors for Infectious Diseases Gaps and Opportunities

M Ackland, Julia Bornhorst, George Dedoussis, Rodney Dietert, Jerome Nriagu, Jozef Pacyna, John Pettifor

(2015), pp. 271-307, TRACE METALS AND INFECTIOUS DISEASES, Frankfurt, GERMANY, B1

book chapter

Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol

G Greene, L Martin, R Tabor, A Michalczyk, L Ackland, R Horn

(2015), Vol. 53, pp. 127-136, Biomaterials, Amsterdam, The Netherlands, C1

journal article

Characterization of two cation diffusion facilitators NpunF0707 and NpunF1794 in Nostoc punctiforme

L Hudek, L Pearson, A Michalczyk, L Brau, B Neilan, M Ackland

(2015), Vol. 119, pp. 1357-1370, Journal of applied microbiology, Weinheim, Germany, C1

journal article

The ZntA-like NpunR4017 plays a key role in maintaining homeostatic levels of zinc in Nostoc punctiforme

L Hudek, L Brau, A Michalczyk, B Neilan, J Meeks, M Ackland

(2015), Vol. 99, pp. 10559-10574, Applied microbiology and biotechnology, New York, N.Y., C1

journal article

Inquisition of Microcystis aeruginosa and Synechocystis nanowires: characterization and modelling

S Sure, A Torriero, A Gaur, L Li, Y Chen, C Tripathi, A Adholeya, M Ackland, M Kochar

(2015), Vol. 108, pp. 1213-1225, Antonie van Leeuwenhoek: international journal of general and molecular microbiology, New York, N.Y., C1

journal article

Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk

L Kumar, A Michalczyk, J McKay, D Ford, T Kambe, L Hudek, G Varigios, P Taylor, M Ackland

(2015), Vol. 10, pp. 487-502, Genes and nutrition, New York, N.Y., C1

journal article
2014

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

J Wadwa, Y Chu, N Nguyen, T Henson, A Figueroa, R Llanos, M Ackland, A Michalczyk, H Fullriede, G Brennan, J Mercer, M Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal article

Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models

D Freestone, M Cater, M Ackland, D Paterson, D Howard, M de Jonge, A Michalczyk

(2014), Vol. 25, pp. 377-387, Journal of Nutritional Biochemistry, New York, NY, C1

journal article

Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures

D Price, M Ackland, W Burks, M Knight, C Suphioglu

(2014), Vol. 33, pp. 1758-1777, Cellular Physiology and Biochemistry, Basel, Switzerland, C1

journal article

Glutaredoxin1 protects neuronal cells from copper-induced toxicity

M Cater, S Materia, Z Xiao, K Wolyniec, S Ackland, Y Yap, N Cheung, S La Fontaine

(2014), Vol. 27, pp. 661-672, Biometals, New York, N.Y., C1

journal article

Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD

R Hamon, C Homan, H Tran, V Mukaro, S Lester, E Roscioli, M Bosco, C Murgia, M Ackland, H Jersmann, C Lang, P Zalewski, S Hodge

(2014), Vol. 9, pp. 1-9, PLoS one, San Francisco, CA, C1

journal article

Comparative analyses of cadmium and zinc uptake correlated with changes in natural resistance-associated macrophage protein (NRAMP) expression in Solanum nigrum L. and Brassica rapa

Y Song, L Hudek, D Freestone, J Puhui, A Michalczyk, Z Senlin, M Ackland

(2014), Vol. 11, pp. 653-660, Environmental Chemistry, Clayton, Vic., C1

journal article
2013

Zinc homeostasis in cyanobacteria

L Hudek, A Michalczyk, B Neilan, M Ackland

(2013), pp. 245-253, Stress biology of cyanobacteria : molecular mechanisms to cellular responses, Boca Raton, Flo., B1-1

book chapter

Composition, sources, and potential toxicology of polycyclic aromatic hydrocarbons (PAHs) in agricultural soils in Liaoning, People's Republic of China

X Cao, M Liu, Y Song, M Ackland

(2013), Vol. 185, pp. 2231-2241, Environmental Monitoring and Assessment, C1

journal article

Functional characterization of the twin ZIP/SLC39 metal transporters, NpunF3111 and NpunF2202 in Nostoc punctiforme

L Hudek, L Pearson, A Michalczyk, B Neilan, M Ackland

(2013), Vol. 97, pp. 8649-8662, Applied Microbiology and Biotechnology, C1

journal article

Molecular and cellular characterisation of the zinc uptake (Znu) system of nostoc punctiforme

L Hudek, L Pearson, A Michalczyk, B Neilan, M Ackland

(2013), Vol. 86, pp. 149-171, FEMS Microbiology Ecology, C1

journal article

HZip1 (hSLC39A1) regulates zinc homoeostasis in gut epithelial cells

A Michalczyk, M Ackland

(2013), Vol. 8, pp. 475-486, Genes and Nutrition, C1

journal article

A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)

C Hogstrand, P Kille, M Ackland, S Hiscox, K Taylor

(2013), Vol. 455, pp. 229-237, Biochemical Journal, C1

journal article

Nuts 'n' guts: transport of food allergens across the intestinal epithelium

D Price, L Ackland, C Suphioglu

(2013), Vol. 3, pp. 257-265, Asia Pacific allergy, Seoul, Korea, C1-1

journal article
2012

Effects of zinc and DHA on the epigenetic regulation of human neuronal cells

N Sadli, M Ackland, D De Mel, A Sinclair, C Suphioglu

(2012), Vol. 29, pp. 87-98, Cellular Physiology and Biochemistry, C1

journal article

Copper levels in buccal cells of vineyard workers engaged in various activities

T Thompson, D Freestone, A Michalczyk, M Ackland

(2012), Vol. 56, pp. 305-314, Annals of Occupational Hygiene, C1

journal article

Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Y Chu, E Sauble, A Cabrera, A Roth, M Ackland, J Mercer, M Linder

(2012), Vol. 25, pp. 373-382, BioMetals, C1

journal article

Physiological metal uptake by Nostoc punctiforme

L Hudek, S Rai, A Michalczyk, L Rai, B Neilan, M Ackland

(2012), Vol. 25, pp. 893-903, BioMetals, C1

journal article

Biochemical responses of earthworm eisenia fetida exposed to cadmium-contaminated soil with long duration

X Yang, Y Song, M Ackland, Y Liu, X Cao

(2012), Vol. 89, pp. 1148-1153, Bulletin of Environmental Contamination and Toxicology, C1

journal article

Contribution of fibroblast and mast cell (afferent) and tumor (efferent) IL-6 effects within the tumor microenvironment

H Hugo, S Lebret, E Tomaskovic-Crook, N Ahmed, T Blick, D Newgreen, E Thompson, M Ackland

(2012), Vol. 5, pp. 83-93, Cancer Microenvironment, C1

journal article
2011

Effect of Zinc and DHA on Expression Levels and Post-Translational Modifications of Histones H3 and H4 in Human Neuronal Cells

Nadia Sadli, Nayyar Ahmed, M Ackland, Andrew Sinclair, Colin Barrow, Cenk Suphioglu

(2011), pp. 141-164, NEURODEGENERATIVE DISEASES - PROCESSES, PREVENTION, PROTECTION AND MONITORING, B1

book chapter

Strategies for enhancing the phytoremediation of cadmium-contaminated agricultural soils by Solanum nigrum L

P Ji, T Sun, Y Song, M Ackland, Y Liu

(2011), Vol. 159, pp. 762-768, Environmental Pollution, C1

journal article

Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta

B Hardman, S Luff, M Ackland

(2011), Vol. 32, pp. 79-85, Placenta, C1

journal article

Dietary zinc mediates inflammation and protects against wasting and metabolic derangement caused by sustained cigarette smoke exposure in mice

C Lang, M Hansen, E Roscioli, J Jones, C Murgia, M Leigh Ackland, P Zalewski, G Anderson, R Ruffin

(2011), Vol. 24, pp. 23-39, BioMetals, C1

journal article

Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway

A Fukunaka, Y Kurokawa, F Teranishi, I Sekler, K Oda, M Ackland, V Faundez, M Hiromura, S Masuda, M Nagao, S Enomoto, T Kambe

(2011), Vol. 286, pp. 16363-16373, Journal of Biological Chemistry, C1

journal article

Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation

C Murgia, D Grosser, A Truong-Tran, E Roscioli, A Michalczyk, M AcKland, M Stoltenberg, G Danscher, C Lang, D Knight, G Perozzi, R Ruffin, P Zalewski

(2011), Vol. 3, pp. 910-928, Nutrients, C1

journal article
2010

Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells

C Suphioglu, N Sadli, D Coonan, L Kumar, D De Mel, J Lesheim, A Sinclair, L Ackland

(2010), Vol. 103, pp. 344-351, British Journal of Nutrition, C1

journal article

The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport

C Suphioglu, D De Mel, L Kumar, N Sadli, D Freestone, A Michalczyk, A Sinclair, M Ackland

(2010), Vol. 584, pp. 612-618, FEBS Letters, C1

journal article

Defining the E-Cadherin repressor interactome in epithelial-mesenchymal transition: The PMC42 model as a case study

H Hugo, M Kokkinos, T Blick, M Ackland, E Thompson, D Newgreen

(2010), Vol. 193, pp. 23-40, Cells Tissues Organs, C1

journal article

Assessing health risk of reclaimed water using human cell culture.

M Ackland, A Michalczyk, D Freestone, F Stagnitti

(2010), Vol. 37, pp. 39-43, Water, St Leonards, N.S.W., C1

journal article

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: Emerging roles

S La Fontaine, M Ackland, J Mercer

(2010), Vol. 42, pp. 206-209, International Journal of Biochemistry and Cell Biology, C1

journal article
2009

Nutritional and functional status indicators in residents of a long-term care facility

J Grieger, C Nowson, L Ackland

(2009), Vol. 28, pp. 47-60, Journal of nutrition for the elderly, New York, N.Y., C1

journal article

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

J Grieger, C Nowson, H Jarman, R Malon, L Ackland

(2009), Vol. 63, pp. 558-565, European Journal of Clinical Nutrition, C1

journal article

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas

M Colomiere, A Ward, C Riley, M Trenerry, D Cameron-Smith, J Findlay, L Ackland, N Ahmed

(2009), Vol. 100, pp. 134-144, British Journal of Cancer, C1

journal article

Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of ?6?1 integrin

M Colomiere, J Findlay, L Ackland, N Ahmed

(2009), Vol. 41, pp. 1034-1045, International Journal of Biochemistry and Cell Biology, C1

journal article

Bioinformatic and expression analyses of genes mediating zinc homeostasis in Nostoc punctiforme

L Hudek, L Rai, D Freestone, A Michalczyk, M Gibson, Y Song, M Leigh Ackland

(2009), Vol. 75, pp. 784-791, Applied and Environmental Microbiology, C1

journal article

??CytP450????????????????????

Y Song, L Wang, X Li, W Zhang, L Chen, D Freestone, P Ji, M Ackland

(2009), Vol. 29, pp. 381-388, Acta scientiae circumstantiae, Beijing, China, C1

journal article

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

K Shield, M Ackland, N Ahmed, G Rice

(2009), Vol. 113, pp. 143-148, Gynecologic Oncology, C1

journal article

Pulse-lavage brushing followed by hydrogen peroxide-gauze packing for bone-bed preparation in cemented total hip arthroplasty: a bovine model.

D Ackland, V Yap, M Ackland, J Williams, R de Steiger

(2009), Vol. 17, pp. 296-300, Journal of orthopaedic surgery (Hong Kong), C1-1

journal article

The response of CytP450 and antioxidant enzymes in plants to phenanthrene and pyrene exposure in soil at lower concentrations

Y Song, X Li, W Zhang, F David, M Ackland, L Chen, P Ji, X Yang

(2009), Vol. 29, pp. 3768-3774, Shengtai Xuebao/ Acta Ecologica Sinica, C1-1

journal article
2008

Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9

S Overbeck, P Uciechowski, M Ackland, D Ford, L Rink

(2008), Vol. 83, pp. 368-380, Journal of Leukocyte Biology, C1

journal article

ATP7B expression in human breast epithelial cells is mediated by lactational hormones

A Michalczyk, E Bastow, M Greenough, J Camakaris, D Freestone, P Taylor, M Linder, J Mercer, M Ackland

(2008), Vol. 56, pp. 389-399, Journal of Histochemistry and Cytochemistry, C1

journal article

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

R Llanos, A Michalczyk, D Freestone, S Currie, M Linder, M Ackland, J Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and Biophysical Research Communications, C1

journal article

Annetocin and TCTP expressions in the earthworm Eisenia fetida exposed to PAHs in artificial soil

S Zheng, Y Song, X Qiu, T Sun, M Leigh Ackland, W Zhang

(2008), Vol. 71, pp. 566-573, Ecotoxicology and Environmental Safety, C1

journal article

Copper is taken up efficiently from albumin and ?2-macroglobulin by cultured human cells by more than one mechanism

M Moriya, Y Ho, A Grana, L Nguyen, A Alvarez, R Jamil, M Ackland, A Michalczyk, P Hamer, D Ramos, S Kim, J Mercer, M Linder

(2008), Vol. 295, pp. 708-721, American journal of physiology: cell physiology, Bethesda, Md., C1

journal article

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S Zheng, Y Song, X Qiu, T Sun, W Zhang, M Ackland

(2008), Vol. 29, pp. 391-397, Chinese journal of environmental science, Beijing, China, C1

journal article
2007

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, M Ackland

(2007), Vol. 402, pp. 241-250, Biochemical Journal, C1

journal article

Epithelial - Mesenchymal and mesenchymal - Epithelial transitions in carcinoma progression

H Hugo, M Ackland, T Blick, M Lawrence, J Clements, E Williams, E Thompson

(2007), Vol. 213, pp. 374-383, Journal of Cellular Physiology, C1

journal article

Genotoxicity assessment of soils from wastewater irrigation areas and bioremediation sites using the Vicia faba root tip micronucleus assay

Y Song, P Gong, B Wilke, W Zhang, X Song, T Sun, M Ackland

(2007), Vol. 9, pp. 182-186, Journal of Environmental Monitoring, C1

journal article

?2?1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

K Shield, C Riley, M Quinn, G Rice, M Ackland, N Ahmed

(2007), Vol. 6, Journal of Carcinogenesis, C1

journal article

Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors

S Lebret, D Newgreen, E Thompson, M Ackland

(2007), Vol. 9, Breast Cancer Research, C1

journal article

Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cells

M Ackland, L Zou, D Freestone, S Van De Waasenburg, A Michalczyk

(2007), Vol. 85, pp. 617-622, Immunology and Cell Biology, C1

journal article

Anthropometric and biochemical markers for nutritional risk among residents within an Australian residential care facility

J Grieger, C Nowson, M Ackland

(2007), Vol. 16, pp. 178-186, Asia Pacific Journal of Clinical Nutrition, C1

journal article

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in human placental cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, M Ackland

(2007), Vol. 20, pp. 1073-1084, Cellular Physiology and Biochemistry, C1

journal article

Effects of low dosage pyrene pollution on biochemical characters of earthworm (Eisenia fetida) in soil

W Zhang, Y Song, T Sun, M Liu, M Ackland, B Galina

(2007), Vol. 18, pp. 2097-2103, Chinese Journal of Applied Ecology, C1

journal article
2006

Expression, Localisation and Hormone Regulation of the Human Copper Transporter hCTR1 in Placenta and Choriocarcinoma Jeg-3 Cells

B Hardman, U Manuelpillai, E Wallace, J Monty, D Kramer, Y Kuo, J Mercer, M Ackland

(2006), Vol. 27, pp. 968-977, Placenta, C1

journal article

Zinc deficiency and its inherited disorders - a review

M Ackland, Agnes Michalczyk

(2006), Vol. 1, pp. 41-49, GENES AND NUTRITION, C1

journal article

Apoptosis may underlie the pathology of zinc-deficient skin

D Wilson, G Varigos, M Ackland

(2006), Vol. 84, pp. 28-37, Immunology and Cell Biology, C1

journal article

Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells

S Lebret, D Newgreen, M Waltham, J Price, E Thompson, M Ackland

(2006), Vol. 42, pp. 298-307, In Vitro Cellular and Developmental Biology - Animal, C1

journal article
2005

Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines.

M Ackland, S van de Waarsenburg, R Jones

(2005), Vol. 19, pp. 69-76, In vivo (Athens, Greece), C1

journal article

Perinatal ?-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood

A Jayasooriya, M Ackland, M Mathai, A Sinclair, H Weisinger, R Weisinger, J Halver, K Kitajka, L Pusks

(2005), Vol. 102, pp. 7133-7138, Proceedings of the National Academy of Sciences of the United States of America, C1

journal article

Synergistic antiproliferation action of the flavonols quercetin and kaempferol in cultured human cancer cell lines

M Ackland, S Van De Waarsenburg, R Jones

(2005), Vol. 19, pp. 69-76, in vivo, Athens, Greece, C1-1

journal article
2004

Fresh and cultured buccal cells as a source of mRNA and protein for molecular analysis

A Michalczyk, G Varigos, L Smith, M Ackland

(2004), Vol. 37, pp. 262-269, BioTechniques, C1

journal article

Expression and localization of Menkes and Wilson Copper transporting ATPases in human placenta

B Hardman, U Manuelpillai, E Wallace, S van de Waasenburg, M Cater, J Mercer, M Ackland

(2004), Vol. 25, pp. 512-517, Placenta, C1

journal article
2003

Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells

M Ackland, D Newgreen, M Fridman, M Waltham, A Arvanitis, J Minichiello, J Price, E Thompson

(2003), Vol. 83, pp. 435-448, Laboratory Investigation, C1

journal article

Analysis of zinc transporter, hZnT4 (SIc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk

A Michalczyk, G Varigos, A Catto-Smith, R Blomeley, M Ackland

(2003), Vol. 113, pp. 202-210, Human Genetics, C1

journal article

Extracellular matrix induces formation of organoids and changes in cell surface morphology in cultured human breast carcinoma cells PMC42-LA

M Ackland, J Ward, C Ackland, M Greaves, M Walker

(2003), Vol. 39, pp. 428-433, In Vitro Cellular and Developmental Biology - Animal, C1-1

journal article
2002

Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells

A Michalczyk, J Allen, R Blomeley, M Ackland

(2002), Vol. 364, pp. 105-113, Biochemical Journal, C1

journal article
2001

PMC42, a novel model for the differentiated human breast

M Ackland, A Michalczyk, R Whitehead

(2001), Vol. 263, pp. 14-22, Experimental Cell Research, C1

journal article

Creatine transporter protein content, localization, and gene expression in rat skeletal muscle

R Murphy, G McConell, D Cameron-Smith, K Watt, L Ackland, B Walzel, T Wallimann, R Snow

(2001), Vol. 280, American Journal of Physiology - Cell Physiology, C1

journal article

Lactation affects expression of intermediate filaments in human breast epithelium

A Michalczyk, R Brown, J Collins, M Ackland

(2001), Vol. 67, pp. 41-49, Differentiation, Amsterdam, The Netherlands, C1-1

journal article
2000

Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation

A Michalczyk, J Rieger, K Allen, J Mercer, M Ackland

(2000), Vol. 352, pp. 565-571, Biochemical journal, London, Eng., C1-1

journal article

Zinc intake and status in Australian vegetarians

M Ball, M Ackland

(2000), Vol. 83, pp. 27-33, British Journal of Nutrition, Cambridge, Eng., C1-1

journal article

Metallothionein isoform expression by breast cancer cells

N Barnes, M Ackland, E Cornish

(2000), Vol. 32, pp. 895-903, The International Journal of Biochemistry & Cell Biology, Oxford, Eng., C1-1

journal article
1999

Expression of Menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk

M Ackland, P Anikijenko, A Michalczyk, J Mercer

(1999), Vol. 47, pp. 1553-1562, Journal of Histochemistry and Cytochemistry, Thousand Oaks, Calif., C1-1

journal article
1997

Expression of Menkes disease gene in mammary carcinoma cells

M Ackland, E Cornish, A Paynter, A Grimes, A Michalczyk, F Mercer

(1997), Vol. 328, pp. 237-243, Biochemical journal, London, Eng., C1-1

journal article
1996

Cation-dependent uptake of zinc in human fibroblasts

M Ackland, H McArdle

(1996), Vol. 9, pp. 29-37, Biometals, Dordrecht, Netherlands, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Molecular Eco-toxicology for diagnosis of priority pollutants in soil

Prof Leigh Ackland, Prof Yufang Song

DEST/ISL Grant - Australian-China Special Fund for Science and Tech Cooperation - Department of Education, Science and Technology - International Science Linkages

  • 2010: $7,000
  • 2007: $23,000

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

ARC Linkage - Projects Rnd 1, ARC_DUAPAI ARC_Deakin University Australian Postgraduate Award Industry

  • 2013: $14,921
  • 2012: $183,043
  • 2011: $159,949
  • 2010: $153,111

Triggering the dormant capacity of fish to make omega 3 fatty acids

Prof Giovanni Turchini, Prof Andrew Sinclair, Prof Leigh Ackland

ARC - Discovery Projects

  • 2014: $57,969
  • 2013: $56,269
  • 2012: $86,138
  • 2011: $82,946
  • 2010: $81,660

The contribution of host caveolin-1 to breast cancer metastasis

A/Prof Robin Anderson, Prof Leigh Ackland

NHMRC Project Grant

  • 2012: $55,000
  • 2011: $55,000
  • 2010: $55,000

Nanoliposomal delivery of DHA to neuronal cells

Prof Leigh Ackland, Prof Andrew Sinclair, A/Prof Cenk Suphioglu, Prof Harjinder Singh

ARC - Discovery Projects

  • 2014: $99,992
  • 2013: $97,059
  • 2012: $103,848

NABNEC: A Randomised Phase II Study Of Nab-paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas

Dr Mustafa Khasraw, A/Prof lara Lipton, Dr Lorraine Chantrill, A/Prof Michael Hofman, Prof Leigh Ackland, A/Prof Michael Michael, Dr Michael Christie, A/Prof Anthony Gill, Ms Kate Wilson

NHMRC Project Grant

  • 2020: $13,214
  • 2019: $31,949
  • 2018: $14,051
  • 2017: $50,656

Multifunctional and environmentally friendly corrosion inhibitor systems

Prof Maria Forsyth, Dr Anthony Somers, Prof Leigh Ackland, Dr Laura Machuca Suarez, Prof Herman Terryn

ARC - Discovery Projects

  • 2020: $115,050
  • 2019: $125,975
  • 2018: $135,268

Other Public Sector Funding

Orion Conductivity Probes

Prof Leigh Ackland

  • 2014: $670

Metastasis in breast cancer cells

Prof Leigh Ackland, Miss Vidhula Ahire

  • 2015: $1,500

Whole exome sequencing and methylation profiling of Neuroendocrine cancers from patients on the NABNEC trial

Dr Mustafa Khasraw, Prof David Ashley, Prof Leigh Ackland

  • 2019: $10,000
  • 2018: $60,000

Industry and Other Funding

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

  • 2012: $70,607
  • 2011: $53,835
  • 2010: $52,910

Establishment of a Biosensor Facility at the Centre for Cellular and Molecular Biology (CCMB), Deakin University, Burwood.

A/Prof Cenk Suphioglu, Prof Leigh Ackland, A/Prof Sharon La Fontaine, Prof Julian Mercer

  • 2011: $50,000

Establishment of a Flow Cytometry Facility at the Centre for Cellular and Molecular Biology, Deakin University

A/Prof Cenk Suphioglu, Prof Leigh Ackland, A/Prof Sharon La Fontaine, Prof Julian Mercer

  • 2010: $30,000

Optimisation of the carotenoid biosynthesis from Haematococcus pluvialis

Dr Angel Torriero, Prof Leigh Ackland

  • 2014: $28,140

Preliminary screening of a saltwater lake sample to identify potentially useful pigment molecules

Dr Angel Torriero, Mr Lee Hudek, Prof Leigh Ackland

  • 2014: $5,000

A Feasibility Study Of NAB-Paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas (NABNEC)

Dr Mustafa Khasraw, Prof Leigh Ackland

  • 2015: $12,500

Characterisation of magnetic or other beads modified with proteins

Prof Leigh Ackland, Dr Angel Torriero

  • 2015: $10,000

Whole exome sequencing and methylation profiling of Neuroendocrine cancers from patients on the NABNEC trial

Dr Mustafa Khasraw, Prof David Ashley, Prof Leigh Ackland

  • 2020: $21,305
  • 2017: $4,570
  • 2016: $4,124

Amplification strategies in point-of-care electrochemical biosensors

Dr Angel Torriero, Prof Leigh Ackland, Dr Ron Chatelier

  • 2019: $40,000
  • 2018: $80,000

Targeting site specific improvements of clinical trial operational processes.

Prof Leigh Ackland

  • 2019: $20,500

Identification of cancer cell markers for early detection

Prof Leigh Ackland

  • 2019: $100,000

Other Funding Sources

Epigenetic markers as indicators of predisposition to diabetes pilot study

Prof Leigh Ackland

  • 2014: $8,000
  • 2012: $45,000

Supervisions

Principal Supervisor
2017

Marije Liem-Weits

Thesis entitled: Tumour microenvironment interations in breast cancer and the role of caveolin-1

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2016

Md Ahsan Ul Bari

Thesis entitled: Effects of Different Forms of Docosahexaenoic Acid Supplementations on Human Neuronal Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

David Freestone

Thesis entitled: Copper Homeostasis in Human Mammary Epithelial Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2012

Lee Hudek

Thesis entitled: Metal Uptake and Efflux Mechanisms in Nostoc Punctiforme

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Lisa Jane McCarthy

Thesis entitled: Assessment of Shark Cartilage Extract from Two Commercially Viable Species

Master of Science (Ecology & Environment), School of Life and Environmental Sciences

2008

Kristy Shield

Thesis entitled: In Vitro Spheroids and Metastatic Epithelial Ovarian Cancer

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2007

Stephanie Chantal Lebret

Thesis entitled: Epithelial-Stromal Interactions in Mammary Lineage Development and Carcinogenesis

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2006

Belinda Mary Hardman

Thesis entitled: Copper Transporters in the Human Placenta

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Agnieszka Michalczyk

Thesis entitled: The Function of Zinc Transporter Genes in Human Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Executive Supervisor
2019

Kiera Rachel Flynn

Thesis entitled: Effects of free fatty acid Docosahexaenoic Acid on supported lipid bilayers

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2017

Shilpi Vajpai

Thesis entitled: Characterisation of chromium interactions with Aspergillus flavus

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2016

Sandeep Karbhari Sure

Thesis entitled: Cyanobacterial Nanowires and Characterisation of Cell-Metalloid/Metal Interactions

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Associate Supervisor
2019

Sharnel Amber Shing Clatworthy

Thesis entitled: Copper in Prostate Cancer: From Basic Science to Therapeutic Investigation

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2016

Ankita Bedi

Thesis entitled: Bioleaching-an approach for synthesizing functionalized nanoformulations for agricultural use

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2015

Nayyar Ahmed

Thesis entitled: Identification and Characterisation of a Novel Interleukin-4 Receptor Antagonist for Allergy Treatment

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Patricia Corbett

Thesis entitled: Histopathological Fish Health Index: a Biomarker of Pollution Effect

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Loveleen Kumar

Thesis entitled: Function of zinc transporters in human cells

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2014

Dwan Price

Thesis entitled: Molecular and immunological analysis of food allergens

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Bianca Jade Sfiligoj

Thesis entitled: Sensitivity of Antarctic marine invertebrates and microalgae to metal exposure

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2012

Nadia Sadli

Thesis entitled: Zinc and docosahexaenoic acid metabolism in brain cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2011

Sara Wilkinson

Thesis entitled: The Relationship between Building Adaptation and Property Attributes

Doctor of Philosophy (Architecture), School of Life and Environmental Sciences

Jane Alisa Allardyce

Thesis entitled: Defence Mechanisms of a Resistant Monocot Model to Phytophthora Cinnamomi

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Tiffany Gunning

Thesis entitled: Profiling Secondary Metabolites of Plant Roots Inoculated with Phytophthora cinnamomi

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Dian Wirawan Tjondronegoro

Thesis entitled: Content-based Video Indexing for Sports Applications using Integrated Multi-Modal Approac

Doctor of Philosophy (Information Technology), School of Information Technology